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Telmivas HZ 12.5/40 Tablet 1 Strip
Telmisartan and Hydrochlorothiazide are used for the treatment of hypertension to lower blood pressure. This medication can be used alone or in combination with other antihypertensive agents. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, including strokes and myocardial infarctions.
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✅ Description:
Telmisartan:
Telmisartan is an angiotensin II receptor blocker (ARB) that prevents the vasoconstriction and aldosterone-secreting effects of angiotensin II by selectively blocking AT1 receptors. It does not inhibit ACE (kininase II), nor does it interact with other hormone receptors or ion channels important in cardiovascular regulation.
Hydrochlorothiazide:
Hydrochlorothiazide is a thiazide diuretic that increases sodium and chloride excretion, leading to plasma volume reduction. This results in an increase in plasma renin activity and aldosterone secretion, which may cause potassium loss. When combined with an ARB, the potassium loss is counteracted.
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✔️ Side Effects
Common side effects include:
- Dizziness, drowsiness, tiredness
- Flushing, nausea, diarrhea, stomach pain
- Leg pain, chest pain, back pain
- Insomnia, dry mouth
Rare but serious adverse effects may include:
- Allergic reactions, fever, photosensitivity
- Myalgia, muscle spasms, gastric irritation
- Elevations in liver enzymes or bilirubin levels
✔️ Dosage & Administration
- Patients are uncontrolled with Telmisartan 80 mg monotherapy: Start with Telmisartan & Hydrochlorothiazide 80 mg/12.5 mg once daily. If necessary, the dose may be increased to 160 mg/25 mg after 2 to 4 weeks.
- Patients on Hydrochlorothiazide 25 mg experiencing hypokalemia: Start with Telmisartan & Hydrochlorothiazide 80 mg/12.5 mg once daily, with the possibility of titrating up to 160 mg/25 mg.
- Combination with other antihypertensive drugs: Telmisartan and Hydrochlorothiazide can be used alongside other antihypertensive agents for better blood pressure control.
✔️ Pediatric Use:
Safety and effectiveness in children have not been established.
✔️ Geriatric Use:
Older patients should start with the lowest effective dose due to possible decreased kidney, liver, or heart function.
✔️ Hepatic Impairment:
Patients with liver disease should take this medication under close medical supervision.
✔️ Renal Impairment:
- Not recommended for patients with severe renal impairment (CrCl <30 ml/min).
- No dose adjustment is needed for mild to moderate renal impairment.
✔️ Caution should be exercised if taking Telmivas HZ alongside:
- Aliskiren (especially in diabetic patients)
- Digoxin, lithium, NSAIDs (aspirin, ibuprofen, naproxen)
- Corticosteroids (prednisone, hydrocortisone)
- ACE inhibitors (benazepril, enalapril, lisinopril)
- Other angiotensin II receptor blockers (losartan, olmesartan, valsartan)
This medication may interfere with certain lab tests (e.g., parathyroid test, protein-bound iodide test), causing false results.
✔️ Contraindications
- Patients with hypersensitivity to Telmisartan, Hydrochlorothiazide, or any component of the formulation.
- Diabetic patients should not take this medication with Aliskiren.
✔️ Pregnancy (Category D):
- This medication can harm fetal renal function if used during the second and third trimesters, leading to complications such as lung hypoplasia and skeletal deformities.
- If pregnancy is detected, discontinue use immediately.
✔️ Lactation:
- It is unknown whether telmisartan is excreted in human milk.
- Thiazides do pass into breast milk and may affect the nursing infant.
- A decision should be made to either discontinue nursing or the medication, based on the mother's needs.
✔️ Symptoms of overdose may include:
- Hypotension, dizziness, tachycardia, bradycardia
- Electrolyte imbalances (hypokalemia, hyponatremia)
- Dehydration
Telmisartan is not removed by hemodialysis, and the extent to which Hydrochlorothiazide is removed is unknown.
✔️ Before taking Telmivas HZ, inform your doctor if you have:
- Kidney or liver disease, bile duct blockage
- Dehydration or mineral imbalances (e.g., potassium levels)
- Gout or lupus
- Diabetes (as it may affect blood sugar levels)
✔️ Precautions & Warnings
- Avoid potassium supplements or salt substitutes containing potassium without consulting a doctor.
- This medication may cause dizziness. Avoid driving or using heavy machinery until you know how it affects you.
- Drink enough fluids to prevent dehydration.
✔️ Storage Conditions
- Store in a cool and dry place, away from light.
- Keep out of reach of children.
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